Ontology highlight
ABSTRACT:
SUBMITTER: Woo LW
PROVIDER: S-EPMC3743159 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
ChemMedChem 20130311 5
4-{[(4-Cyanophenyl)(4H-1,2,4-triazol-4-yl)amino]methyl}phenyl sulfamate and its ortho-halogenated (F, Cl, Br) derivatives are first-generation dual aromatase and sulfatase inhibitors (DASIs). Structure-activity relationship studies were performed on these compounds, and various modifications were made to their structures involving relocation of the halogen atom, introduction of more halogen atoms, replacement of the halogen with another group, replacement of the methylene linker with a difluorom ...[more]