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Solid-phase methodology for synthesis of O-alkylated aromatic oligoamide inhibitors of ?-helix-mediated protein-protein interactions.

ABSTRACT: Rapid access to rigid rods: A method is described for the synthesis of 3-O-alkylated aromatic oligobenzamide foldamers that could be used for assembly of libraries of ?-helix mimetic inhibitors of protein-protein interactions (see scheme; Fmoc=9-fluorenylmethoxycarbonyl).

SUBMITTER: Murphy NS

PROVIDER: S-EPMC3743211 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature

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Solid-phase methodology for synthesis of O-alkylated aromatic oligoamide inhibitors of α-helix-mediated protein-protein interactions.

Murphy Natasha S NS Prabhakaran Panchami P Azzarito Valeria V Plante Jeffrey P JP Hardie Michaele J MJ Kilner Colin A CA Warriner Stuart L SL Wilson Andrew J AJ

Chemistry (Weinheim an der Bergstrasse, Germany) 20130318 18

Rapid access to rigid rods: A method is described for the synthesis of 3-O-alkylated aromatic oligobenzamide foldamers that could be used for assembly of libraries of α-helix mimetic inhibitors of protein-protein interactions (see scheme; Fmoc=9-fluorenylmethoxycarbonyl). ...[more]

PMID: 23508712

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