Ontology highlight
ABSTRACT:
SUBMITTER: Dong T
PROVIDER: S-EPMC3743462 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Dong Tao T Zhang Yonghong Y Xu Ke Yi KY Yan Huiping H James Ian I Peng Yanchun Y Blais Marie-Eve ME Gaudieri Silvana S Chen Xinyue X Lun Wenhui W Wu Hao H Qu Wen Yan WY Rostron Tim T Li Ning N Mao Yu Y Mallal Simon S Xu Xiaoning X McMichael Andrew A John Mina M Rowland-Jones Sarah L SL
Blood 20110511 1
Obstacles to developing an HIV-1 vaccine include extensive viral diversity and lack of correlates of protective immunity. High mutation rates allow HIV-1 to adapt rapidly to selective forces such as antiretroviral therapy and immune pressure, including HIV-1-specific CTLs that select viral variants which escape T-cell recognition. Multiple factors contribute to HIV-1 diversity, making it difficult to disentangle the contribution of CTL selection without using complex analytical approaches. We de ...[more]