SFAs do not impair endothelial function and arterial stiffness.

ABSTRACT:

Background

It is uncertain whether saturated fatty acids (SFAs) impair endothelial function and contribute to arterial stiffening.

Objective

We tested the effects of replacing SFAs with monounsaturated fatty acids (MUFAs) or carbohydrates on endothelial function and arterial stiffness.

Design

With the use of a parallel-designed randomized controlled trial in 121 insulin-resistant men and women, we measured vascular function after 1 mo of consumption of a high-SFA (HS) diet and after 24 wk after random assignment to the HS diet or diets that contained <10% SFAs and were high in either MUFAs or carbohydrates. The primary outcome was a change in flow-mediated dilation (FMD), and secondary outcomes were changes in carotid to femoral pulse wave velocity (PWV) and plasma 8-

SUBMITTER: Sanders TA 

PROVIDER: S-EPMC3743730 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature