The prognostic significance of IRF8 transcripts in adult patients with acute myeloid leukemia.

ABSTRACT: Interferon regulatory factor 8 (IRF8) is a transcription factor that plays a critical role in normal hematopoiesis, such that disruption of IRF8 activity promotes leukemogenesis. We and others have identified aberrant expression of IRF8 transcripts, including novel splice variants, in acute myeloid leukemia (AML), but studies have not investigated the prognostic significance of these transcripts. Therefore, we developed and optimized quantitative expression assays for both, the wild type, or the reference sequence (WT-IRF8) and novel splice variants (SV-IRF8). These assays were used to quantify IRF8 transcript levels in 194 adult patients with AML, and multivariate analyses investigated the prognostic significance of these expression levels. After adjusting for known prognostic factors, ex

SUBMITTER: Pogosova-Agadjanyan EL 

PROVIDER: S-EPMC3743845 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature