Ontology highlight
ABSTRACT:
SUBMITTER: Papadakis M
PROVIDER: S-EPMC3744134 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Papadakis Michalis M Hadley Gina G Xilouri Maria M Hoyte Lisa C LC Nagel Simon S McMenamin M Mary MM Tsaknakis Grigorios G Watt Suzanne M SM Drakesmith Cynthia Wright CW Chen Ruoli R Wood Matthew J A MJ Zhao Zonghang Z Kessler Benedikt B Vekrellis Kostas K Buchan Alastair M AM
Nature medicine 20130224 3
Previous attempts to identify neuroprotective targets by studying the ischemic cascade and devising ways to suppress it have failed to translate to efficacious therapies for acute ischemic stroke. We hypothesized that studying the molecular determinants of endogenous neuroprotection in two well-established paradigms, the resistance of CA3 hippocampal neurons to global ischemia and the tolerance conferred by ischemic preconditioning (IPC), would reveal new neuroprotective targets. We found that t ...[more]