Human fibroblasts for large-scale "omics" investigations of ATM gene function.
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ABSTRACT:
SUBMITTER: Jung M
PROVIDER: S-EPMC3744187 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Publications
Human fibroblasts for large-scale "omics" investigations of ATM gene function.
Jung Mira M Timofeeva Olga O Cheema Amrita K AK Varghese Rency R Ressom Habtom H Dritschilo Anatoly A
Advances in experimental medicine and biology 20110101
ATM (gene mutated in ataxia-telangiectasia) is a critical central component of the pleiotropic responses of cells to ionizing radiation-induced stress. To gain insight into molecular mechanisms and to enhance our understanding of ATM functions, we have advanced a human model cell system, derived from genetically defined immortal fibroblasts, and we have applied high-throughput genomic, proteomic and metabolomic technologies for a systems level analysis. The cellular characterizations reported he ...[more]
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