Geometry of protein shape and its evolutionary pattern for function prediction and characterization.
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ABSTRACT:
SUBMITTER: Liang J
PROVIDER: S-EPMC3744228 | biostudies-literature | 2009
REPOSITORIES: biostudies-literature
Publications
Geometry of protein shape and its evolutionary pattern for function prediction and characterization.
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference 20090101
Proteins contain thousands or more atoms and have complex shapes. We discuss here the computation of protein packing defects, in the form of voids and pockets, from experimentally resolved protein structures, and the nature of their distribution and scaling behavior, as well as their origin. We further discuss how evolutionary selection pressure due to biological function unaltered by selection pressure due to constraints from folding and stability can be isolated and estimated, and how such inf ...[more]
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