Unknown

Dataset Information

0

Resilin-Based Hybrid Hydrogels for Cardiovascular Tissue Engineering.


ABSTRACT: The outstanding elastomeric properties of natural resilin, an insect protein, have motivated the engineering of resilin-like polypeptides (RLPs) as a potential material for cardiovascular tissue engineering. The RLPs, which incorporate biofunctional domains for cell-matrix interactions, are cross-linked into RLP-PEG hybrid hydrogels via a Michael-type addition of cysteine residues on the RLP with vinyl sulfones of an end-functionalized multi-arm star PEG. Oscillatory rheology indicated the useful mechanical properties of these materials. Assessments of cell viability via con-focal microscopy clearly show the successful encapsulation of human aortic adventitial fibroblasts in the three-dimensional matrices and the adoption of a spread morphology following 7 days of culture.

SUBMITTER: McGann CL 

PROVIDER: S-EPMC3744378 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature

altmetric image

Publications

Resilin-Based Hybrid Hydrogels for Cardiovascular Tissue Engineering.

McGann Christopher L CL   Levenson Eric A EA   Kiick Kristi L KL  

Macromolecules 20130101 2


The outstanding elastomeric properties of natural resilin, an insect protein, have motivated the engineering of resilin-like polypeptides (RLPs) as a potential material for cardiovascular tissue engineering. The RLPs, which incorporate biofunctional domains for cell-matrix interactions, are cross-linked into RLP-PEG hybrid hydrogels via a Michael-type addition of cysteine residues on the RLP with vinyl sulfones of an end-functionalized multi-arm star PEG. Oscillatory rheology indicated the usefu  ...[more]

Similar Datasets

| S-EPMC6776424 | biostudies-literature
| S-EPMC8271496 | biostudies-literature
| S-EPMC6030450 | biostudies-literature
| S-EPMC4850080 | biostudies-literature
| S-EPMC5201005 | biostudies-literature
| S-EPMC4009447 | biostudies-literature
| S-EPMC5753891 | biostudies-other
| S-EPMC6585131 | biostudies-literature
| S-EPMC8022864 | biostudies-literature
| S-EPMC7079155 | biostudies-literature