Ontology highlight
ABSTRACT:
SUBMITTER: Iwamori N
PROVIDER: S-EPMC3744460 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Iwamori Naoki N Iwamori Tokuko T Matzuk Martin M MM
PloS one 20130815 8
The spermatogonial stem cell (SSC) compartment is maintained by self-renewal of stem cells as well as fragmentation of differentiating spermatogonia through abscission of intercellular bridges in a random and stochastic manner. The molecular mechanisms that regulate this reversible developmental lineage remain to be elucidated. Here, we show that histone H3K27 demethylase, JMJD3 (KDM6B), regulates the fragmentation of spermatogonial cysts. Down-regulation of Jmjd3 in SSCs promotes an increase in ...[more]