Ontology highlight
ABSTRACT:
SUBMITTER: Rask-Andersen M
PROVIDER: S-EPMC3744548 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Rask-Andersen Mathias M Moschonis George G Chrousos George P GP Marcus Claude C Dedoussis George V GV Fredriksson Robert R Schiöth Helgi B HB
PloS one 20130815 8
Recent genome wide association studies (GWAS) have identified a locus on chromosome 11p15.5, closely associated with serine/threonine kinase 33 (STK33), to be associated with body mass. STK33, a relatively understudied protein, has been linked to KRAS mutation-driven cancers and explored as a potential antineoplastic drug target. The strongest association with body mass observed at this loci in GWAS was rs4929949, a single nucleotide polymorphism located within intron 1 of the gene encoding STK3 ...[more]