Ontology highlight
ABSTRACT:
SUBMITTER: Kim JS
PROVIDER: S-EPMC3744711 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Kim Ju Seung JS Ahn Sung-Min SM Jung Young Kul YK Kwon Oh Sang OS Kim Yun Soo YS Choi Duck Joo DJ Kim Ju Hyun JH
Journal of Korean medical science 20130731 8
<h4>Two variants of the inosine triphosphatase (itpa</h4>rs1127354, rs7270101) gene cause ITPA deficiency and protect against the hemolytic toxicity of ribavirin. We investigated the clinical significance of ITPA variants in Korean patients treated with pegylated interferon (PEG-IFN) plus ribavirin. Of the 133 patients, 108 were CC and 25 were non-CC at rs1127354 (groups A and B, respectively). On the other hand, at rs7270101 all 133 were AA. The mean values of Hemoglobin (Hgb) after 4, 8, and 1 ...[more]