Ontology highlight
ABSTRACT:
SUBMITTER: Ren A
PROVIDER: S-EPMC3744881 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Ren Aiming A Rajashankar Kanagalaghatta R KR Patel Dinshaw J DJ
Nature 20120513 7401
Significant advances in our understanding of RNA architecture, folding and recognition have emerged from structure-function studies on riboswitches, non-coding RNAs whose sensing domains bind small ligands and whose adjacent expression platforms contain RNA elements involved in the control of gene regulation. We now report on the ligand-bound structure of the Thermotoga petrophila fluoride riboswitch, which adopts a higher-order RNA architecture stabilized by pseudoknot and long-range reversed W ...[more]