Ontology highlight
ABSTRACT:
SUBMITTER: Cagnetta A
PROVIDER: S-EPMC3744991 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Cagnetta Antonia A Cea Michele M Calimeri Teresa T Acharya Chirag C Fulciniti Mariateresa M Tai Yu-Tzu YT Hideshima Teru T Chauhan Dharminder D Zhong Mike Y MY Patrone Franco F Nencioni Alessio A Gobbi Marco M Richardson Paul P Munshi Nikhil N Anderson Kenneth C KC
Blood 20130703 7
We recently demonstrated that Nicotinamide phosphoribosyltransferase (Nampt) inhibition depletes intracellular NAD⁺ content leading, to autophagic multiple myeloma (MM) cell death. Bortezomib has remarkably improved MM patient outcome, but dose-limiting toxicities and development of resistance limit its long-term utility. Here we observed higher Nampt messenger RNA levels in bortezomib-resistant patient MM cells, which correlated with decreased overall survival. We demonstrated that combining th ...[more]