Ontology highlight
ABSTRACT:
SUBMITTER: Yang S
PROVIDER: S-EPMC3745427 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
PloS one 20130816 8
The protein TIN2 is a member of telomere-binding protein complex that serves to cap and protect mammalian chromosome ends. As a number of proteins in this complex are phosphorylated in a cell cycle-dependent manner, we investigated whether TIN2 is modified by phosphorylation as well. We performed phospho-proteomic analysis of human TIN2, and identified two phosphorylated residues, serines 295 and 330. We demonstrated that both these sites were phosphorylated during mitosis in human cells, as det ...[more]