Ontology highlight
ABSTRACT:
SUBMITTER: Wallace JA
PROVIDER: S-EPMC3745457 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Wallace Julie A JA Li Fu F Balakrishnan Subhasree S Cantemir-Stone Carmen Z CZ Pecot Thierry T Martin Chelsea C Kladney Raleigh D RD Sharma Sudarshana M SM Trimboli Anthony J AJ Fernandez Soledad A SA Yu Lianbo L Rosol Thomas J TJ Stromberg Paul C PC Lesurf Robert R Hallett Michael M Park Morag M Leone Gustavo G Ostrowski Michael C MC
PloS one 20130816 8
Tumor fibroblasts are active partners in tumor progression, but the genes and pathways that mediate this collaboration are ill-defined. Previous work demonstrates that Ets2 function in stromal cells significantly contributes to breast tumor progression. Conditional mouse models were used to study the function of Ets2 in both mammary stromal fibroblasts and epithelial cells. Conditional inactivation of Ets2 in stromal fibroblasts in PyMT and ErbB2 driven tumors significantly reduced tumor growth, ...[more]