Ontology highlight
ABSTRACT:
SUBMITTER: Oumata N
PROVIDER: S-EPMC3745460 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Oumata Nassima N Nguyen Phu Hai PH Beringue Vincent V Soubigou Flavie F Pang Yanhong Y Desban Nathalie N Massacrier Catherine C Morel Yannis Y Paturel Carine C Contesse Marie-Astrid MA Bouaziz Serge S Sanyal Suparna S Galons Hervé H Blondel Marc M Voisset Cécile C
PloS one 20130816 8
Using a yeast-based assay, a previously unsuspected antiprion activity was found for imiquimod (IQ), a potent Toll-like receptor 7 (TLR7) agonist already used for clinical applications. The antiprion activity of IQ was first detected against yeast prions [PSI (+) ] and [URE3], and then against mammalian prion both ex vivo in a cell-based assay and in vivo in a transgenic mouse model for prion diseases. In order to facilitate structure-activity relationship studies, we conducted a new synthetic p ...[more]