A central role for inducible heat-shock protein 70 in autoimmune vitiligo.
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ABSTRACT:
SUBMITTER: Mosenson JA
PROVIDER: S-EPMC3745819 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Publications
A central role for inducible heat-shock protein 70 in autoimmune vitiligo.
Mosenson Jeffrey A JA Eby Jonathan M JM Hernandez Claudia C Le Poole I Caroline IC
Experimental dermatology 20130620 9
Inducible heat-shock protein 70 (HSP70i) is a protein regulated by stress that protects cells from undergoing apoptosis. Such proteins are marvellously well conserved throughout evolution, which has placed them in the spotlight for helping to understand the intriguing relationship between infection and immunity. In the presence of stress proteins, dendritic cells (DCs) will sense this alarm signal and respond by recruiting immune cells of different plumage to fit the occasion. In times of stress ...[more]
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