Ontology highlight
ABSTRACT:
SUBMITTER: Span I
PROVIDER: S-EPMC3745992 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Nature communications 20120101
The final step of the methylerythritol phosphate isoprenoid biosynthesis pathway is catalysed by the iron-sulphur enzyme IspH, producing the universal precursors of terpenes: isopentenyl diphosphate and dimethylallyl diphosphate. Here we report an unforeseen reaction discovered during the investigation of the interaction of IspH with acetylene inhibitors by X-ray crystallography, Mößbauer, and nuclear magnetic resonance spectroscopy. In addition to its role as a 2H(+)/2e(-) reductase, IspH can h ...[more]