Ontology highlight
ABSTRACT:
SUBMITTER: Suzuki J
PROVIDER: S-EPMC3746548 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
Suzuki Junko J Chen Yunn-Yi YY Scott Gary K GK Devries Sandy S Chin Koei K Benz Christopher C CC Waldman Frederic M FM Hwang E Shelley ES
Clinical cancer research : an official journal of the American Association for Cancer Research 20090421 9
<h4>Purpose</h4>Excess histone deacetylase (HDAC) activity can induce hypoacetylation of histone and nonhistone protein substrates, altering gene expression patterns and cell behavior potentially associated with malignant transformation. However, HDAC expression and protein acetylation have not been studied in the context of breast cancer progression.<h4>Experimental design</h4>We assessed expression levels of acetylated histone H4 (ac-H4), ac-H4K12, ac-tubulin, HDAC1, HDAC2, and HDAC6 in 22 red ...[more]