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Tracking injectable microspheres in dynamic tissues with encapsulated superparamagnetic iron oxide nanoparticles.

ABSTRACT: Trackable spheres of similar size to those typically used for sustained protein delivery are prepared by incorporating superparamagnetic iron oxide (SPIO) nanoparticles into the core of poly(lactide-co-glycolide) microspheres. The visibility of injections in static and temporally in dynamic tissue systems is demonstrated. This method improves upon other, less sensitive imaging modalities in their ability to track injectable delivery systems. The results obtained confirm the localization of microspheres to the injected target area and highlight the novelty of tracking delivery vehicles for other applications.

SUBMITTER: Franklin-Ford T 

PROVIDER: S-EPMC3746814 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature

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Tracking injectable microspheres in dynamic tissues with encapsulated superparamagnetic iron oxide nanoparticles.

Franklin-Ford Travelle T   Shah Nehal N   Leiferman Ellen E   Chamberlain Connie S CS   Raval Amish A   Vanderby Ray R   Murphy William L WL  

Macromolecular bioscience 20121101 12

Trackable spheres of similar size to those typically used for sustained protein delivery are prepared by incorporating superparamagnetic iron oxide (SPIO) nanoparticles into the core of poly(lactide-co-glycolide) microspheres. The visibility of injections in static and temporally in dynamic tissue systems is demonstrated. This method improves upon other, less sensitive imaging modalities in their ability to track injectable delivery systems. The results obtained confirm the localization of micro  ...[more]

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