Dataset Information

Sex, race, and the development of acute lung injury.

ABSTRACT:

Background

Prior studies suggest that mortality differs by sex and race in patients who develop acute lung injury (ALI). Whether differences in presentation account for these disparities remains unclear. We sought to determine whether sexual and racial differences exist in the rate of ALI development and ALI-related mortality after accounting for differences in clinical presentations.

Methods

This was a multicenter, observational cohort study of 5,201 patients at risk for ALI. Multivariable logistic regression with adjustment for center-level effects was used to adjust for potential covariates.

Results

The incidence of ALI development was 5.9%; in-hospital mortality was 5.0% for the entire cohort, and 24.4% for those patients who developed ALI. Men were more likely to develop ALI compared to women (6.9% vs 4.7%, P , .001) and had a nonsignificant increase in mortality when ALI developed (27.6% vs 18.5%, P 5 .08). However, after adjustment for baseline imbalances between sexes these differences were no longer significant. Black patients, compared to white patients, presented more frequently with pneumonia, sepsis, or shock and had higher severity of illness. Black patients were less likely to develop ALI than whites (4.5% vs. 6.5%, P 5 .014), and this association remained statistically significant after adjusting for differences in presentation (OR, 0.66; 95 % CI, 0.45-0.96).

Conclusions

Sex and race differences exist in the clinical presentation of patients at risk of developing ALI. After accounting for differences in presentation, there was no sex difference in ALI development and outcome. Black patients were less likely to develop ALI despite increased severity of illness on presentation.

SUBMITTER: Lemos-Filho LB

PROVIDER: S-EPMC3747719 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature

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Publications

Sex, race, and the development of acute lung injury.

Lemos-Filho Luciano B LB Mikkelsen Mark E ME Martin Greg S GS Dabbagh Ousama O Adesanya Adebola A Gentile Nina N Esper Annette A Gajic Ognjen O Gong Michelle N MN

Chest 20130401 4

<h4>Background</h4>Prior studies suggest that mortality differs by sex and race in patients who develop acute lung injury (ALI). Whether differences in presentation account for these disparities remains unclear. We sought to determine whether sexual and racial differences exist in the rate of ALI development and ALI-related mortality after accounting for differences in clinical presentations.<h4>Methods</h4>This was a multicenter, observational cohort study of 5,201 patients at risk for ALI. Mul ...[more]

PMID: 23117155

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Dataset Information

Sex, race, and the development of acute lung injury.

Background

Methods

Results

Conclusions

Publications

Sex, race, and the development of acute lung injury.

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