Ontology highlight
ABSTRACT:
SUBMITTER: Fukuda M
PROVIDER: S-EPMC3747952 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Fukuda Makoto M Williams Kevin W KW Gautron Laurent L Elmquist Joel K JK
Cell metabolism 20110301 3
Leptin regulates energy balance and glucose homeostasis. Shortly after leptin was identified, it was established that obesity is commonly associated with leptin resistance, though the molecular mechanisms remain to be identified. To explore potential mechanisms of leptin resistance, we employed organotypic brain slices to identify candidate signaling pathways that negatively regulate leptin sensitivity. We found that elevation of adenosine 3', 5'-monophosphate (cAMP) levels impairs multiple sign ...[more]