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Preoperative platelet count associates with survival and distant metastasis in surgically resected colorectal cancer patients.

ABSTRACT: Platelets have been implicated in cancer metastasis and prognosis. No population-based study has been reported as to whether preoperative platelet count directly predicts metastatic recurrence of colorectal cancer (CRC) patients.Using a well-characterized cohort of 1,513 surgically resected CRC patients, we assessed the predictive roles of preoperative platelet count in overall survival, overall recurrence, as well as locoregional and distant metastatic recurrences.Patients with clinically high platelet count (?400?× 10(9)/L) measured within 1 month before surgery had a significantly unfavorable survival (hazard ratio [HR]?=?1.66, 95 % confidence interval [CI] 1.34-2.05, P?=?2.6?×?10(-6), P(log rank)?=?1.1?×?10(-11)) and recurrence (HR?=?1.90, 1.24-2.93, P?=?0.003, P(log rank)?=?0.003). The association of platelet count with recurrence was evident only in patients with metastatic (HR?=?2.81, 1.67-4.74, P?=?1.1?×?10(-4), P(log rank)?=?2.6?×?10(-6)) but not locoregional recurrence (HR?=?0.59, 95 % CI 0.21-1.68, P?=?0.325, P(log rank)?=?0.152). The findings were internally validated through bootstrap resampling (P?

SUBMITTER: Wan S

PROVIDER: S-EPMC3748145 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature

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Preoperative platelet count associates with survival and distant metastasis in surgically resected colorectal cancer patients.

Wan Shaogui S Lai Yinzhi Y Myers Ronald E RE Li Bingshan B Hyslop Terry T London Jack J Chatterjee Devjani D Palazzo Juan P JP Burkart Ashlie L AL Zhang Kejin K Xing Jinliang J Yang Hushan H

Journal of gastrointestinal cancer 20130901 3

<h4>Objective</h4>Platelets have been implicated in cancer metastasis and prognosis. No population-based study has been reported as to whether preoperative platelet count directly predicts metastatic recurrence of colorectal cancer (CRC) patients.<h4>Design</h4>Using a well-characterized cohort of 1,513 surgically resected CRC patients, we assessed the predictive roles of preoperative platelet count in overall survival, overall recurrence, as well as locoregional and distant metastatic recurrenc ...[more]

PMID: 23549858

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Project description:BackgroundColorectal cancer (CRC) is the third most common malignancy in males and the second most common in females worldwide. Distant metastases have a strong negative impact on the prognosis of CRC patients. The most common site of CRC metastases is the liver. Both disease progression and metastasis have been related to the patient's peripheral blood monocyte count. We therefore performed a case-control study to assess the relationship between the preoperative peripheral blood monocyte count and colorectal liver metastases (CRLM).MethodsClinical data from 117 patients with colon cancer and 93 with rectal cancer who were admitted to the Chinese People's Liberation Army General Hospital (Beijing, China) between December 2003 and May 2015 were analysed retrospectively, with the permission of both the patients and the hospital.ResultsPreoperative peripheral blood monocyte counts, the T and N classifications of the primary tumour and its primary site differed significantly between the two groups (P < 0.001, P < 0.001, P = 0.002, P < 0.001), whereas there were no differences in the sex, age, degree of tumour differentiation or largest tumour diameter. Lymph node metastasis and a high preoperative peripheral blood monocyte count were independent risk factors for liver metastasis (OR: 2.178, 95%CI: 1.148~4.134, P = 0.017; OR: 12.422, 95%CI: 5.076~30.398, P < 0.001), although the risk was lower in patients with rectal versus colon cancer (OR: 0.078, 95%CI: 0.020~0.309, P < 0.001). Primary tumour site (P<0.001), degree of tumour differentiation (P = 0.009), T, N and M classifications, TNM staging and preoperative monocyte counts (P<0.001) were associated with the 5-year overall survival (OS) of CRC patients. A preoperative peripheral blood monocyte count > 0.505 × 109 cells/L, high T classification and liver metastasis were independent risk factors for 5-year OS (RR: 2.737, 95% CI: 1.573~ 4.764, P <0.001; RR: 2.687, 95%CI: 1.498~4.820, P = 0.001; RR: 4.928, 95%CI: 2.871~8.457, P < 0.001).ConclusionsThe demonstrated association between preoperative peripheral blood monocyte count and liver metastasis in patients with CRC recommends the former as a useful predictor of postoperative prognosis in CRC patients.

Dataset Information

Preoperative platelet count associates with survival and distant metastasis in surgically resected colorectal cancer patients.

Publications

Preoperative platelet count associates with survival and distant metastasis in surgically resected colorectal cancer patients.

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