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Skeletal muscle adiposity is associated with serum lipid and lipoprotein levels in Afro-Caribbean men.

ABSTRACT: When compared with other ethnic groups, African ancestry individuals have lower triglycerides and higher High-density lipoprotein cholesterol (HDL-C) levels, although the mechanisms for these differences remain unclear. A comprehensive array of factors potentially related to fasting serum lipid and lipoprotein levels in African ancestry men was evaluated.Men (1,821) underwent dual-energy X-ray absorptiometry measures of total body fat and quantitative computed tomography assessments of calf skeletal muscle adiposity [subcutaneous and intermuscular adipose tissue (AT), and muscle density as a measure of intra-muscular AT].Multivariable linear regression analysis identified age (-), total body fat (+), subcutaneous AT (-), fasting glucose (+), fasting insulin (+), diastolic blood pressure (+), and non-African ancestry (+) as independent correlates of triglycerides (all P < 0.05). Total body fat (+), intra-muscular AT (-), and diastolic blood pressure (+) were independent correlates of Low-density lipoprotein cholesterol (LDL-C) (all P < 0.001). Age (+), waist circumference (-), fasting insulin (-), physical activity (+), and alcohol intake (+) were independent correlates of HDL-C (all P < 0.05).A novel relationship between skeletal muscle adiposity and serum lipid and lipoprotein levels in African ancestry men, independent of total and central adiposity was illuminated. In African ancestry populations, genetic factors are likely a significant determinant of triglycerides levels.

SUBMITTER: Miljkovic I

PROVIDER: S-EPMC3748155 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature

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Skeletal muscle adiposity is associated with serum lipid and lipoprotein levels in Afro-Caribbean men.

Miljkovic I I Kuipers A L AL Kuller L H LH Sheu Y Y Bunker C H CH Patrick A L AL Wheeler V W VW Evans R W RW Zmuda J M JM

Obesity (Silver Spring, Md.) 20130513 9

<h4>Objective</h4>When compared with other ethnic groups, African ancestry individuals have lower triglycerides and higher High-density lipoprotein cholesterol (HDL-C) levels, although the mechanisms for these differences remain unclear. A comprehensive array of factors potentially related to fasting serum lipid and lipoprotein levels in African ancestry men was evaluated.<h4>Design and methods</h4>Men (1,821) underwent dual-energy X-ray absorptiometry measures of total body fat and quantitative ...[more]

PMID: 23671057

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Project description:BackgroundProspective studies examining the potential association of vitamin D with age-related muscle loss have shown inconsistent results.ObjectiveTo examine the association between baseline serum 25-hydroxyvitamin D (25(OH)D), 1,25-dihydroxyvitamin D (1,25(OH)2D), and prospective change in lean mass with aging in African ancestry population. We also determined if associations were modulated by age and diabetes mellitus (DM).DesignProspective observational cohort study.SettingData were collected from a random sub-sample of 574 men, participants of the Tobago Bone Health Study (TBHS).Participants574 Afro-Caribbean men, aged 43+ years (mean age: 59.1 ± 10.5), who were randomly selected as the participants in both the baseline and the follow-up visits.MeasurementsBaseline fasting serum 25(OH)D was measured using liquid chromatography mass spectrometry (LC-MS/MS), and and 1,25(OH)2D was measured using radioimmunosassay (RIA). Changes in dual-energy X-ray absorptiometry (DXA)-measured appendicular lean mass (ALM), and total body lean mass (TBLM) were measured over an average of 6.0 ± 0.5 years. The associations of 25(OH)D and 1,25(OH)2D with ALM and TBLM were assessed by multiple linear regression model after adjusting for potential confounders.ResultsWhen stratifying all men into two groups by age, greater baseline 25(OH)D and 1,25(OH)2D levels were associated with smaller losses of ALM and TBLM in older (age 60+ years) but not in younger (age 43 - 59 years) men. When stratifying by DM status, the associations of 25(OH)D and 1,25(OH)2D with declines in ALM and TBLM were statistically significant only in prediabetic, but not among normal glycemic or diabetic men.ConclusionHigher endogenous vitamin D concentrations are associated with less lean mass loss with aging among older and prediabetic Afro-Caribbean men independent of potential confounders. Our findings raise a possibility that maintaining high serum vitamin D level might be important for musculoskeletal health in elderly and prediabetic African ancestry men.

Dataset Information

Skeletal muscle adiposity is associated with serum lipid and lipoprotein levels in Afro-Caribbean men.

Publications

Skeletal muscle adiposity is associated with serum lipid and lipoprotein levels in Afro-Caribbean men.

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