Ontology highlight
ABSTRACT:
SUBMITTER: Cabrera S
PROVIDER: S-EPMC3748191 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Cabrera Sandra S Fernández Alvaro F AF Mariño Guillermo G Aguirre Alina A Suárez María F MF Español Yaiza Y Vega José A JA Laurà Rosaria R Fueyo Antonio A Fernández-García M Soledad MS Freije José M P JM Kroemer Guido G López-Otín Carlos C
Autophagy 20130508 8
The identification of inflammatory bowel disease (IBD) susceptibility genes by genome-wide association has linked this pathology to autophagy, a lysosomal degradation pathway that is crucial for cell and tissue homeostasis. Here, we describe autophagy-related 4B, cysteine peptidase/autophagin-1 (ATG4B) as an essential protein in the control of inflammatory response during experimental colitis. In this pathological condition, ATG4B protein levels increase in parallel with the induction of autopha ...[more]