Evaluating the prognostic significance of preoperative thrombocytosis in epithelial ovarian cancer.

ABSTRACT:

Objective

Preoperative thrombocytosis has been implicated as a negative prognostic marker for epithelial ovarian cancer (EOC). We assessed whether thrombocytosis is an independent risk factor for EOC recurrence and death.

Methods

Perioperative patient characteristics and process-of-care variables (National Surgical Quality Improvement Program (NSQIP)-defined) were retrospectively abstracted from 587 women who underwent EOC staging between 1/2/03-12/29/08. Thrombocytosis was defined as platelet count > 450 × 10(9)/L. Disease-free survival (DFS) and overall survival (OS) were determined using Kaplan-Meier methods. Associations were evaluated with Cox proportional hazards regression and hazard ratios (HR).

Results

The incidence of preoperative thrombocytosis was 22.3%. D

SUBMITTER: Allensworth SK 

PROVIDER: S-EPMC3748213 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature