Ontology highlight
ABSTRACT:
SUBMITTER: Chang YP
PROVIDER: S-EPMC3748285 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Cell reports 20130328 4
The DNA tumor virus Simian virus 40 (SV40) is a model system for studying eukaryotic replication. SV40 large tumor antigen (LTag) is the initiator/helicase that is essential for genome replication. LTag recognizes and assembles at the viral replication origin. We determined the structure of two multidomain LTag subunits bound to origin DNA. The structure reveals that the origin binding domains (OBDs) and Zn and AAA+ domains are involved in origin recognition and assembly. Notably, the OBDs recog ...[more]