Ontology highlight
ABSTRACT:
SUBMITTER: Putz EM
PROVIDER: S-EPMC3748339 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Cell reports 20130808 3
The transcription factor STAT1 is important in natural killer (NK) cells, which provide immediate defense against tumor and virally infected cells. We show that mutation of a single phosphorylation site (Stat1-S727A) enhances NK cell cytotoxicity against a range of tumor cells, accompanied by increased expression of perforin and granzyme B. Stat1-S727A mice display significantly delayed disease onset in NK cell-surveilled tumor models including melanoma, leukemia, and metastasizing breast cancer ...[more]