Ontology highlight
ABSTRACT:
SUBMITTER: Antony R
PROVIDER: S-EPMC3748389 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Antony Rajee R Emery Caroline M CM Sawyer Allison M AM Garraway Levi A LA
Cancer research 20130604 15
Melanomas that contain B-RAF(V600E) mutations respond transiently to RAF and MEK inhibitors; however, resistance to these agents remains a formidable challenge. Although B- or C-RAF dysregulation represents prominent resistance mechanisms, resistance-associated point mutations in RAF oncoproteins are surprisingly rare. To gain insights herein, we conducted random mutagenesis screens to identify B- or C-RAF mutations that confer resistance to RAF inhibitors. Whereas bona fide B-RAF(V600E) resista ...[more]