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The role of mechanical loading in tendon development, maintenance, injury, and repair.

ABSTRACT: Tendon injuries often result from excessive or insufficient mechanical loading, impairing the ability of the local tendon cell population to maintain normal tendon function. The resident cell population composing tendon tissue is mechanosensitive, given that the cells are able to alter the extracellular matrix in response to modifications of the local loading environment. Natural tendon healing is insufficient, characterized by improper collagen fibril diameter formation, collagen fibril distribution, and overall fibril misalignment. Current tendon repair rehabilitation protocols focus on implementing early, well-controlled eccentric loading exercises to improve repair outcome. Tissue engineers look toward incorporating mechanical loading regimens to precondition cell populations for the creation of improved biological augmentations for tendon repair.

SUBMITTER: Galloway MT

PROVIDER: S-EPMC3748997 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature

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The role of mechanical loading in tendon development, maintenance, injury, and repair.

Galloway Marc T MT Lalley Andrea L AL Shearn Jason T JT

The Journal of bone and joint surgery. American volume 20130901 17

Tendon injuries often result from excessive or insufficient mechanical loading, impairing the ability of the local tendon cell population to maintain normal tendon function. The resident cell population composing tendon tissue is mechanosensitive, given that the cells are able to alter the extracellular matrix in response to modifications of the local loading environment. Natural tendon healing is insufficient, characterized by improper collagen fibril diameter formation, collagen fibril distrib ...[more]

PMID: 24005204

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