Artificial repressors for controlling gene expression in bacteria.
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ABSTRACT:
SUBMITTER: Politz MC
PROVIDER: S-EPMC3749042 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Publications
Artificial repressors for controlling gene expression in bacteria.
Politz Mark C MC Copeland Matthew F MF Pfleger Brian F BF
Chemical communications (Cambridge, England) 20121210 39
Transcriptional repression is a common approach to control gene expression in synthetic biology applications. Here, an engineered DNA binding protein based upon a transcription activator-like effector (TALE) scaffold was shown to outperform LacI in blocking transcription from a promoter and to repress expression of a downstream gene in an operon. ...[more]
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