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Artificial repressors for controlling gene expression in bacteria.


ABSTRACT: Transcriptional repression is a common approach to control gene expression in synthetic biology applications. Here, an engineered DNA binding protein based upon a transcription activator-like effector (TALE) scaffold was shown to outperform LacI in blocking transcription from a promoter and to repress expression of a downstream gene in an operon.

SUBMITTER: Politz MC 

PROVIDER: S-EPMC3749042 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature

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Artificial repressors for controlling gene expression in bacteria.

Politz Mark C MC   Copeland Matthew F MF   Pfleger Brian F BF  

Chemical communications (Cambridge, England) 20121210 39


Transcriptional repression is a common approach to control gene expression in synthetic biology applications. Here, an engineered DNA binding protein based upon a transcription activator-like effector (TALE) scaffold was shown to outperform LacI in blocking transcription from a promoter and to repress expression of a downstream gene in an operon. ...[more]

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