Mnt1p and Mnt2p of Candida albicans are partially redundant alpha-1,2-mannosyltransferases that participate in O-linked mannosylation and are required for adhesion and virulence.
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ABSTRACT:
SUBMITTER: Munro CA
PROVIDER: S-EPMC3749086 | biostudies-literature | 2005 Jan
REPOSITORIES: biostudies-literature
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Mnt1p and Mnt2p of Candida albicans are partially redundant alpha-1,2-mannosyltransferases that participate in O-linked mannosylation and are required for adhesion and virulence.
Munro Carol A CA Bates Steven S Buurman Ed T ET Hughes H Bleddyn HB Maccallum Donna M DM Bertram Gwyneth G Atrih Abdel A Ferguson Michael A J MA Bain Judith M JM Brand Alexandra A Hamilton Suzanne S Westwater Caroline C Thomson Lynn M LM Brown Alistair J P AJ Odds Frank C FC Gow Neil A R NA
The Journal of biological chemistry 20041101 2
The MNT1 gene of the human fungal pathogen Candida albicans is involved in O-glycosylation of cell wall and secreted proteins and is important for adherence of C. albicans to host surfaces and for virulence. Here we describe the molecular analysis of CaMNT2, a second member of the MNT1-like gene family in C. albicans. Mnt2p also functions in O-glycosylation. Mnt1p and Mnt2p encode partially redundant alpha-1,2-mannosyltransferases that catalyze the addition of the second and third mannose residu ...[more]
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