Ontology highlight
ABSTRACT:
SUBMITTER: Ghosh-Roy S
PROVIDER: S-EPMC3749123 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Ghosh-Roy Sounak S Das Dhiman D Chowdhury Debarati D Smerdon Michael J MJ Chaudhuri Ronita Nag RN
PloS one 20130821 8
Transcription coupled nucleotide excision repair (TCR) is a major pathway responsible for removal of helix distorting DNA lesions from transcriptionally active regions of the genome. Rad26, a key factor of the TCR pathway, is known to play a role during early steps of TCR. Here, we show that Rad26-mediated TCR is not absolutely dependent on active transcription elongation in budding yeast. As per our results, RAD26-deleted cells show enhanced UV sensitivity compared to wild type cells under cond ...[more]