Ontology highlight
ABSTRACT:
SUBMITTER: St John AL
PROVIDER: S-EPMC3749235 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
St John Ashley L AL Chan Cheryl Y CY Staats Herman F HF Leong Kam W KW Abraham Soman N SN
Nature materials 20120122 3
Granules of mast cells (MCs) enhance adaptive immunity when, on activation, they are released as stable particles. Here we show that submicrometre particles modelled after MC granules augment immunity when used as adjuvants in vaccines. The synthetic particles, which consist of a carbohydrate backbone with encapsulated inflammatory mediators such as tumour necrosis factor, replicate attributes of MCs in vivo including the targeting of draining lymph nodes and the timed release of the encapsulate ...[more]