Ontology highlight
ABSTRACT:
SUBMITTER: Cufi S
PROVIDER: S-EPMC3749547 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Cufí Sílvia S Vazquez-Martin Alejandro A Oliveras-Ferraros Cristina C Corominas-Faja Bruna B Cuyàs Elisabet E López-Bonet Eugeni E Martin-Castillo Begoña B Joven Jorge J Menendez Javier A JA
Scientific reports 20130101
Autophagy may control the de novo refractoriness of HER2 gene-amplified breast carcinomas to the monoclonal antibody trastuzumab (Herceptin). Tumor cells originally obtained from a patient who rapidly progressed on trastuzumab ab initio display increased cellular levels of the LC3-II protein--a finding that correlates with increased numbers of autophagosomes--and decreased levels of the autophagy receptor p62/SQSTM1, a protein selectively degraded by autophagy. Trastuzumab-refractory cells are i ...[more]