Cancer genome landscapes.
Ontology highlight
ABSTRACT:
SUBMITTER: Vogelstein B
PROVIDER: S-EPMC3749880 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Publications
Cancer genome landscapes.
Vogelstein Bert B Papadopoulos Nickolas N Velculescu Victor E VE Zhou Shibin S Diaz Luis A LA Kinzler Kenneth W KW
Science (New York, N.Y.) 20130301 6127
Over the past decade, comprehensive sequencing efforts have revealed the genomic landscapes of common forms of human cancer. For most cancer types, this landscape consists of a small number of "mountains" (genes altered in a high percentage of tumors) and a much larger number of "hills" (genes altered infrequently). To date, these studies have revealed ~140 genes that, when altered by intragenic mutations, can promote or "drive" tumorigenesis. A typical tumor contains two to eight of these "driv ...[more]
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