A self-directed method for cell-type identification and separation of gene expression microarrays.
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ABSTRACT:
SUBMITTER: Zuckerman NS
PROVIDER: S-EPMC3749952 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Publications
A self-directed method for cell-type identification and separation of gene expression microarrays.
Zuckerman Neta S NS Noam Yair Y Goldsmith Andrea J AJ Lee Peter P PP
PLoS computational biology 20130822 8
Gene expression analysis is generally performed on heterogeneous tissue samples consisting of multiple cell types. Current methods developed to separate heterogeneous gene expression rely on prior knowledge of the cell-type composition and/or signatures--these are not available in most public datasets. We present a novel method to identify the cell-type composition, signatures and proportions per sample without need for a-priori information. The method was successfully tested on controlled and s ...[more]
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