Association of plasma and cortical amyloid beta is modulated by APOE ?4 status.
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ABSTRACT:
SUBMITTER: Swaminathan S
PROVIDER: S-EPMC3750076 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Publications
Association of plasma and cortical amyloid beta is modulated by APOE ε4 status.
Swaminathan Shanker S Risacher Shannon L SL Yoder Karmen K KK West John D JD Shen Li L Kim Sungeun S Inlow Mark M Foroud Tatiana T Jagust William J WJ Koeppe Robert A RA Mathis Chester A CA Shaw Leslie M LM Trojanowski John Q JQ Soares Holly H Aisen Paul S PS Petersen Ronald C RC Weiner Michael W MW Saykin Andrew J AJ
Alzheimer's & dementia : the journal of the Alzheimer's Association 20130326 1
<h4>Background</h4>Apolipoprotein E (APOE) ε4 allele's role as a modulator of the relationship between soluble plasma amyloid beta (Aβ) and fibrillar brain Aβ measured by Pittsburgh compound B positron emission tomography ([(11)C]PiB PET) has not been assessed.<h4>Methods</h4>Ninety-six Alzheimer's Disease Neuroimaging Initiative participants with [(11)C]PiB scans and plasma Aβ1-40 and Aβ1-42 measurements at the time of PET scanning were included. Regional and voxelwise analyses of [(11)C]PiB da ...[more]
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