Ontology highlight
ABSTRACT:
SUBMITTER: Orso F
PROVIDER: S-EPMC3750217 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Orso Francesca F Balzac Fiorella F Marino Marco M Lembo Antonio A Retta Saverio Francesco SF Taverna Daniela D
Biochemical and biophysical research communications 20130718 1
miR-21 is overexpressed in tumors and it displays oncogenic activity. Here, we show that expression of miR-21 in primary tumors anticorrelates with KRIT1/CCM1, an interacting partner of the Ras-like GTPase Rap1, involved in Cerebral Cavernous Malformations (CCM). We present evidences that miR-21 silences KRIT1 by targeting its mRNA 3'UTR and that this interaction is involved in tumor growth control. In fact, miR-21 over-expression or KRIT1 knock-down promote anchorage independent tumor cell grow ...[more]