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MiR-21 coordinates tumor growth and modulates KRIT1 levels.


ABSTRACT: miR-21 is overexpressed in tumors and it displays oncogenic activity. Here, we show that expression of miR-21 in primary tumors anticorrelates with KRIT1/CCM1, an interacting partner of the Ras-like GTPase Rap1, involved in Cerebral Cavernous Malformations (CCM). We present evidences that miR-21 silences KRIT1 by targeting its mRNA 3'UTR and that this interaction is involved in tumor growth control. In fact, miR-21 over-expression or KRIT1 knock-down promote anchorage independent tumor cell growth compared to controls, whereas the opposite is observed when anti-miR-21 or KRIT1 overexpression are employed. Our findings suggest that miR-21 promotes tumor cell growth, at least in part, by down-modulating the potential tumor suppressor KRIT1.

SUBMITTER: Orso F 

PROVIDER: S-EPMC3750217 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature

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miR-21 coordinates tumor growth and modulates KRIT1 levels.

Orso Francesca F   Balzac Fiorella F   Marino Marco M   Lembo Antonio A   Retta Saverio Francesco SF   Taverna Daniela D  

Biochemical and biophysical research communications 20130718 1


miR-21 is overexpressed in tumors and it displays oncogenic activity. Here, we show that expression of miR-21 in primary tumors anticorrelates with KRIT1/CCM1, an interacting partner of the Ras-like GTPase Rap1, involved in Cerebral Cavernous Malformations (CCM). We present evidences that miR-21 silences KRIT1 by targeting its mRNA 3'UTR and that this interaction is involved in tumor growth control. In fact, miR-21 over-expression or KRIT1 knock-down promote anchorage independent tumor cell grow  ...[more]

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