Ontology highlight
ABSTRACT:
SUBMITTER: Song W
PROVIDER: S-EPMC3750675 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
ACS chemical neuroscience 20130530 8
MMP-9 plays a detrimental role in the pathology of several neurological diseases and, thus, represents an important target for intervention. The water-soluble prodrug ND-478 is hydrolyzed to the active MMP-9 inhibitor ND-322, which in turn is N-acetylated to the even more potent metabolite ND-364. We used a sensitive bioanalytical method based on ultraperformance liquid chromatography with multiple-reaction monitoring detection to measure levels of ND-478, ND-322, and ND-364 in plasma and brain ...[more]