Ontology highlight
ABSTRACT:
SUBMITTER: Rada-Iglesias A
PROVIDER: S-EPMC3751405 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
Cell stem cell 20120913 5
Neural crest cells (NCC) are a transient, embryonic cell population characterized by unusual migratory ability and developmental plasticity. To annotate and characterize cis-regulatory elements utilized by the human NCC, we coupled a hESC differentiation model with genome-wide profiling of histone modifications and of coactivator and transcription factor (TF) occupancy. Sequence analysis predicted major TFs binding at epigenomically annotated hNCC enhancers, including a master NC regulator, TFAP ...[more]