Unknown

Dataset Information

0

Interspecies protein-protein interaction network construction for characterization of host-pathogen interactions: a Candida albicans-zebrafish interaction study.


ABSTRACT: BACKGROUND: Despite clinical research and development in the last decades, infectious diseases remain a top global problem in public health today, being responsible for millions of morbidities and mortalities each year. Therefore, many studies have sought to investigate host-pathogen interactions from various viewpoints in attempts to understand pathogenic and defensive mechanisms, which could help control pathogenic infections. However, most of these efforts have focused predominately on the host or the pathogen individually rather than on a simultaneous analysis of both interaction partners. RESULTS: In this study, with the help of simultaneously quantified time-course Candida albicans-zebrafish interaction transcriptomics and other omics data, a computational framework was developed to construct the interspecies protein-protein interaction (PPI) network for C. albicans-zebrafish interactions based on the inference of ortholog-based PPIs and the dynamic modeling of regulatory responses. The identified C. albicans-zebrafish interspecies PPI network highlights the association between C. albicans pathogenesis and the zebrafish redox process, indicating that redox status is critical in the battle between the host and pathogen. CONCLUSIONS: Advancing from the single-species network construction method, the interspecies network construction approach allows further characterization and elucidation of the host-pathogen interactions. With continued accumulation of interspecies transcriptomics data, the proposed method could be used to explore progressive network rewiring over time, which could benefit the development of network medicine for infectious diseases.

SUBMITTER: Wang YC 

PROVIDER: S-EPMC3751520 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

altmetric image

Publications

Interspecies protein-protein interaction network construction for characterization of host-pathogen interactions: a Candida albicans-zebrafish interaction study.

Wang Yu-Chao YC   Lin Che C   Chuang Ming-Ta MT   Hsieh Wen-Ping WP   Lan Chung-Yu CY   Chuang Yung-Jen YJ   Chen Bor-Sen BS  

BMC systems biology 20130816


<h4>Background</h4>Despite clinical research and development in the last decades, infectious diseases remain a top global problem in public health today, being responsible for millions of morbidities and mortalities each year. Therefore, many studies have sought to investigate host-pathogen interactions from various viewpoints in attempts to understand pathogenic and defensive mechanisms, which could help control pathogenic infections. However, most of these efforts have focused predominately on  ...[more]

Similar Datasets

| S-EPMC3760836 | biostudies-literature
| S-EPMC4135803 | biostudies-other
| S-EPMC4305985 | biostudies-literature
| S-EPMC6741531 | biostudies-literature
| S-EPMC4363425 | biostudies-literature
| S-EPMC5550964 | biostudies-literature
| S-EPMC11008552 | biostudies-literature
| S-EPMC4645408 | biostudies-literature
| S-EPMC4204156 | biostudies-literature
| S-EPMC6693483 | biostudies-literature