Ontology highlight
ABSTRACT:
SUBMITTER: Swanson L
PROVIDER: S-EPMC3751903 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Swanson Lucas L Robertson Gordon G Mungall Karen L KL Butterfield Yaron S YS Chiu Readman R Corbett Richard D RD Docking T Roderick TR Hogge Donna D Jackman Shaun D SD Moore Richard A RA Mungall Andrew J AJ Nip Ka Ming KM Parker Jeremy D K JD Qian Jenny Qing JQ Raymond Anthony A Sung Sandy S Tam Angela A Thiessen Nina N Varhol Richard R Wang Sherry S Yorukoglu Deniz D Zhao Yongjun Y Hoodless Pamela A PA Sahinalp S Cenk SC Karsan Aly A Birol Inanc I
BMC genomics 20130814
<h4>Background</h4>Chimeric transcripts, including partial and internal tandem duplications (PTDs, ITDs) and gene fusions, are important in the detection, prognosis, and treatment of human cancers.<h4>Results</h4>We describe Barnacle, a production-grade analysis tool that detects such chimeras in de novo assemblies of RNA-seq data, and supports prioritizing them for review and validation by reporting the relative coverage of co-occurring chimeric and wild-type transcripts. We demonstrate applica ...[more]