Ontology highlight
ABSTRACT:
SUBMITTER: Kao SY
PROVIDER: S-EPMC3752395 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Neurobiology of disease 20130420
Osteoprotegerin (OPG) is a key regulator of bone remodeling. Mutations and variations in the OPG gene cause many human diseases that are characterized by not only skeletal abnormalities but also poorly understood hearing loss: Paget's disease, osteoporosis, and celiac disease. To gain insight into the mechanisms of hearing loss in OPG deficiency, we studied OPG knockout (Opg(-/-)) mice. We show that they develop sensorineural hearing loss, in addition to conductive hearing loss due to abnormal m ...[more]