Ontology highlight
ABSTRACT:
SUBMITTER: Canzio D
PROVIDER: S-EPMC3752404 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Canzio Daniele D Chang Evelyn Y EY Shankar Smita S Kuchenbecker Kristopher M KM Simon Matthew D MD Madhani Hiten D HD Narlikar Geeta J GJ Al-Sady Bassem B
Molecular cell 20110101 1
HP1 proteins are central to the assembly and spread of heterochromatin containing histone H3K9 methylation. The chromodomain (CD) of HP1 proteins specifically recognizes the methyl mark on H3 peptides, but the same extent of specificity is not observed within chromatin. The chromoshadow domain of HP1 proteins promotes homodimerization, but this alone cannot explain heterochromatin spread. Using the S. pombe HP1 protein, Swi6, we show that recognition of H3K9-methylated chromatin in vitro relies ...[more]