Dataset Information

Distinct relationships of intramuscular and subcutaneous fat with cortical bone: findings from a cross-sectional study of young adult males and females.

ABSTRACT:

Context

Intracellular fat within muscle and visceral tissue has been suggested to adversely influence bone development.

Objective

The aim of the study was to evaluate associations between im fat, as reflected by muscle density as measured by peripheral quantitative computed tomography, and cortical bone parameters in young adults.

Design/setting/participants

We conducted a cross-sectional analysis of 1703 males and 2243 females aged 17.8 years from the Avon Longitudinal Study of Parents and Children.

Outcome measures

We measured cortical bone parameters from midtibial peripheral quantitative computed tomography scans.

Results

Muscle density (inversely related to im fat) was inversely associated with periosteal circumference (PC) (beta = -0.07 [95% confidence interval (CI), -0.1, -0.04]), cortical bone mineral density (BMDC) (beta = -0.21 [95% CI, -0.26, -0.17]), and cortical thickness (CT) (beta = -0.37 [95% CI, -0.42, -0.33]) (males and females combined, adjusted for age, height, gender, and muscle cross-sectional area). In contrast, sc fat area was positively associated with PC (beta = 0.10 [95% CI, 0.07, 0.12]), but no association was seen with BMDC or CT. To examine the role of candidate intermediary metabolic pathways, analyses were repeated after adjustment for insulin, C-reactive protein, and ?-C-telopeptides of type I collagen. Whereas similar associations were observed after adjustment for insulin and C-reactive protein, the association between muscle density and BMDC was partially attenuated by adjustment for ?-C-telopeptides of type I collagen (beta = -0.14 [95% CI, -0.20, -0.08]).

Conclusion

Although im and sc fat were both positively associated with cortical bone mass, the nature of these relationships differed in that im fat was predominantly associated with CT and BMDC, whereas sc fat was mainly associated with PC. These relationships were largely independent of candidate metabolic pathways, such as altered bone resorption, insulin resistance, or inflammation.

SUBMITTER: Deere K

PROVIDER: S-EPMC3752522 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature

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Publications

Distinct relationships of intramuscular and subcutaneous fat with cortical bone: findings from a cross-sectional study of young adult males and females.

Deere K K Sayers A A Viljakainen H T HT Lawlor D A DA Sattar N N Kemp J P JP Fraser W D WD Tobias J H JH

The Journal of clinical endocrinology and metabolism 20130326 6

<h4>Context</h4>Intracellular fat within muscle and visceral tissue has been suggested to adversely influence bone development.<h4>Objective</h4>The aim of the study was to evaluate associations between im fat, as reflected by muscle density as measured by peripheral quantitative computed tomography, and cortical bone parameters in young adults.<h4>Design/setting/participants</h4>We conducted a cross-sectional analysis of 1703 males and 2243 females aged 17.8 years from the Avon Longitudinal Stu ...[more]

PMID: 23533224

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Dataset Information

Distinct relationships of intramuscular and subcutaneous fat with cortical bone: findings from a cross-sectional study of young adult males and females.

Context

Objective

Design/setting/participants

Outcome measures

Results

Conclusion

Publications

Distinct relationships of intramuscular and subcutaneous fat with cortical bone: findings from a cross-sectional study of young adult males and females.

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