Ontology highlight
ABSTRACT:
SUBMITTER: Jung JI
PROVIDER: S-EPMC3752532 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Jung Joo In JI Ladd Thomas B TB Kukar Thomas T Price Ashleigh R AR Moore Brenda D BD Koo Edward H EH Golde Todd E TE Felsenstein Kevin M KM
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20130528 9
Aggregation and accumulation of Aβ42 play an initiating role in Alzheimer's disease (AD); thus, selective lowering of Aβ42 by γ-secretase modulators (GSMs) remains a promising approach to AD therapy. Based on evidence suggesting that steroids may influence Aβ production, we screened 170 steroids at 10 μM for effects on Aβ42 secreted from human APP-overexpressing Chinese hamster ovary cells. Many acidic steroids lowered Aβ42, whereas many nonacidic steroids actually raised Aβ42. Studies on the mo ...[more]