Ontology highlight
ABSTRACT:
SUBMITTER: Gonzalez-Montalban N
PROVIDER: S-EPMC3752540 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20130531 9
Interspecies prion transmission often leads to stable changes in physical and biological features of prion strains, a phenomenon referred to as a strain mutation. It remains unknown whether changes in the replication environment in the absence of changes in PrP primary structure can be a source of strain mutations. To approach this question, RNA content was altered in the course of amplification of hamster strains in serial protein misfolding cyclic amplification (sPMCAb). On adaptation to an RN ...[more]