Low brain DHA content worsens sensorimotor outcomes after TBI and decreases TBI-induced Timp1 expression in juvenile rats.
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ABSTRACT:
SUBMITTER: Russell KL
PROVIDER: S-EPMC3753049 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
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Low brain DHA content worsens sensorimotor outcomes after TBI and decreases TBI-induced Timp1 expression in juvenile rats.
Russell Kristin L KL Berman Nancy E J NE Levant Beth B
Prostaglandins, leukotrienes, and essential fatty acids 20130621 2-3
The effects of dietary modulation of brain DHA content on outcomes after TBI were examined in a juvenile rat model. Long-Evans rats with normal or diet-induced decreases in brain DHA were subjected to a controlled cortical impact or sham surgery on postnatal day 17. Rats with the greatest decreases in brain DHA had the poorest sensorimotor outcomes after TBI. Ccl2, Gfap, and Mmp 9 mRNA levels, and MMP-2 and -9 enzymatic activities were increased after TBI regardless of brain DHA level. Lesion vo ...[more]
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